| 发明名称 |
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCER |
| 摘要 |
The present invention relates to methods and pharmaceutical compositions for the treatment of cancer. In particular, the present invention relates to a polypeptide comprising or consisting of i) an amino acid sequence ranging from the phenylalanine residue at position 380 to the leucine residue at position 384 in SEQ ID NO: 1 or, ii) an amino acid sequence having at least 70% of identity with the amino acid sequence ranging from the phenylalanine residue at position 380 to the leucine residue at position 384 in SEQ ID NO: 1, or iii) an amino acid sequence which is a retro-inverso of the amino acid sequence ranging from the phenylalanine residue at position 380 to the leucine residue at position 384 in SEQ ID NO: 1 or, iv) an amino acid sequence which is retro-inverso of the amino acid sequence having at least 70% of identity with the amino acid sequence ranging from the phenylalanine residue at position 380 to the leucine residue at position 384 in SEQ ID NO: 1. |
| 申请公布号 |
US2017058010(A1) |
申请公布日期 |
2017.03.02 |
| 申请号 |
US201515119274 |
申请日期 |
2015.02.17 |
| 申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ;UNIVERSITÉ PARIS DIDEROT - PARIS 7 ;ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) |
发明人 |
POYET Jean-Luc;BRUZZONI-GIOVANELLI Heriberto;JAGOT-LACOUSSIERE Léonard |
| 分类号 |
C07K14/47;C12N7/00;C07K14/005 |
主分类号 |
C07K14/47 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polypeptide which comprises or consists of:
i) an amino acid sequence ranging from a phenylalanine residue at position 380 to a leucine residue at position 384 in SEQ ID NO:1 or, ii) an amino acid sequence having at least 70% of identity with the amino acid sequence ranging from the phenylalanine residue at position 380 to the leucine residue at position 384 in SEQ ID NO:1, or iii) an amino acid sequence which is a retro-inverso of the amino acid sequence ranging from the phenylalanine residue at position 380 to the leucine residue at position 384 in SEQ ID NO:1 or, iv) an amino acid sequence which is retro-inverso of the amino acid sequence having at least 70% of identity with the amino acid sequence ranging from the phenylalanine residue at position 380 to the leucine residue at position 384 in SEQ ID NO:1, wherein the polypeptide does not consist of the amino acid sequence SEQ ID NO:1 and does not consist of the amino acid sequence ranging from an alanine residue at position 363 to a threonine residue at position 399 in SEQ ID NO: 1. |
| 地址 |
Paris FR |
