发明名称 |
Bosutinib Forms and Preparation Methods Thereof |
摘要 |
The present subject matter relates to solvates and the amorphous form of bosutinib; the solvates namely being a propylene glycol solvate and an acetonitrile solvate. Also provided are processes for preparing the propylene glycol solvate, the amorphous form and the crystalline acetonitrile solvate of bosutinib; as well as compositions comprising said forms. Bosutinib is a 3-quinolinecarbonitrile kinase inhibitor and is indicated for the treatment of adult patients with chronic, accelerated, or blast phase Ph+ chronic myelogenous leukemia (CMS) with resistance or intolerance to prior therapy. |
申请公布号 |
US2017057923(A1) |
申请公布日期 |
2017.03.02 |
申请号 |
US201515120226 |
申请日期 |
2015.02.20 |
申请人 |
Apotex Inc. |
发明人 |
Akbarali Padiyath Mohammed;Kintali Venkata Ramana;Murthy Heggadde Nanjunda Bhatta Shreenivasa;Meenkere Girisha;Venkata Somanath Bhupal;Manda Raja Ramesh;Sodha Vishal Amrutlal;Kante Abbulu |
分类号 |
C07D215/54 |
主分类号 |
C07D215/54 |
代理机构 |
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代理人 |
|
主权项 |
1. A crystalline propylene glycol solvate of Bosutinib. |
地址 |
Toronto CA |