发明名称 |
USE OF LONGITUDINALLY DISPLACED NANOSCALE ELECTRODES FOR VOLTAGE SENSING OF BIOMOLECULES AND OTHER ANALYTES IN FLUIDIC CHANNELS |
摘要 |
Devices and methods for detecting an analyte are provided. Devices for voltage sensing of analytes may comprise a fluidic channel defined in a substrate, a pair of sensing electrodes disposed in a fluidic channel for sensing voltage therein, and a pair of electromotive electrodes for applying potential along the fluidic channel. The pair of sensing electrodes may include a first and second sensing electrode disposed at two discrete locations along the length of the fluidic channel and the pair of electromotive electrodes may be disposed at a first end and a second end of the fluidic channel. The fluidic channel may include a nanochannel or a microchannel. Methods for detecting an analyte may include the steps of disposing the analyte in a fluidic channel; applying a potential along the fluidic channel to generate an electrophoretic force therein such that the analyte is translocated from a first end of the fluidic channel to a second end of the fluidic channel; and measuring a voltage signal between a pair of sensing electrodes disposed in the fluidic channel as the analyte moves past the sensing electrodes. |
申请公布号 |
EP2342362(B1) |
申请公布日期 |
2017.03.01 |
申请号 |
EP20090807476 |
申请日期 |
2009.09.03 |
申请人 |
Nabsys 2.0 LLC |
发明人 |
LING, Xinsheng;BREADY, Barrett;OLIVER, John, S.;JOUZI, Maryam;PETROSSIAN, Leo |
分类号 |
B82Y15/00;G01N33/487 |
主分类号 |
B82Y15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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