| 主权项 |
1. A compound represented by Formula I: including all stereoisomers, geometric isomers, and tautomers; or a pharmaceutically acceptable salt or solvate of any of the foregoing; wherein: A1 is phenylene; A2 is R1 represents independently for each occurrence halogen or haloalkyl; R2 is hydrogen or alkyl; R3 is aryl, aralkyl, cycloalkyl, —(C(R8)2)m-cycloalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, —(C(R8)2)m-heterocycloalkyl, alkyl, haloalkyl, hydroxyalkyl, —(C(R8)2)m-alkoxyl, —(C(R8)2)m—O—(C(R8)2)m-alkoxyl, or —(C(R8)2)m—CN, wherein said aryl, aralkyl, cycloalkyl, heteroaryl, heteroaralkyl, and heterocycloalkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, hydroxyalkyl, C1-C6alkoxy, cyano, and —C1-C6alkylene-CO2R8; R4 is hydrogen or alkyl; R5 is hydrogen or alkyl; R6 is alkyl, cycloalkyl, haloalkyl, cyano, aryl, aralkyl, heteroaryl, heteroaralkyl, —CO2R8, or —C(O)N(R10)(R11), wherein said cycloalkyl, aryl, aralkyl, heteroaryl, and heteroaralkyl are each optionally substituted with 1 or 2 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, hydroxyalkyl, C1-C6alkoxy, —O-aralkyl, and cyano; R7 is hydrogen, halogen, alkyl, or haloalkyl; R8 represents independently for each occurrence hydrogen, alkyl, or cycloalkyl; or two occurrences of R8 attached to the same carbon atom are taken together with said carbon atom to form a saturated carbocylic ring; R10 and R11 each represent independently for each occurrence hydrogen, alkyl, or cycloalkyl; or R10 and R11 are taken together with the nitrogen atom to which they are attached to form a 3 to 7 membered heterocyclic ring optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, and C1-C6alkoxy; n is 1, 2, or 3; and m is 1, 2, 3, 4, or 5. |
