| 发明名称 | Theramutein modulators | ||
| 摘要 | This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein. | ||
| 申请公布号 | US9579326(B2) | 申请公布日期 | 2017.02.28 |
| 申请号 | US201414297863 | 申请日期 | 2014.06.06 |
| 申请人 | HMI MEDICAL INNOVATIONS, LLC | 发明人 | Housey Gerard M. |
| 分类号 | C07D213/81;A61K31/5377;C07D213/87;C07D215/50;C07D231/14;C07D239/42;C07D239/48;C07D239/84;C07D253/065;C07D401/12;C07D405/12;C07D409/12;G01N33/574;C07C243/38;C07D213/77;C07D213/86;C07D215/38;C07D253/075;C07D403/12;G01N33/573;A61K31/47;A61K31/4709;A61K31/505;A61K31/506;A61K31/53;G01N33/50 | 主分类号 | C07D213/81 |
| 代理机构 | Andrews Kurth Kenyon LLP | 代理人 | Andrews Kurth Kenyon LLP |
| 主权项 | 1. A method of identifying a substance which inhibits or activates the functioning of a theramutein in a cell, which comprises: a) providing a test cell which expresses the theramutein and elicits a detectable phenoresponse; b) treating the test cell with the substance; c) examining the treated cell to determine whether the phenoresponse is modulated by treatment with the substance. | ||
| 地址 | Southfield MI US | ||