| 摘要 |
Nafcillin sodium drug intermediates 2-ethoxy naphthalene synthesis method, comprising the following steps: equipped with a stirrer and a reflux condenser, the reaction vessel was added 1.2mol P naphthol (2), 230-260ml ethylamine solution (3), controlling the stirring speed 130-170rpm, 110ml phosphoric acid solution was slowly added, raised the solution temperature to 80--86 C, reflux for 15-17h, cooled and poured into 1.5L sodium sulfite solution, stirred for 90-120min, the precipitated crystals were filtered, washed with salt solution, washed with acetamide solution, recrystallized from ethyl acetate , crystals were dissolved in chlorobenzene, vacuum distillation, collecting the distillate of 120--129 C , got 2-ethoxy naphthalene. |
