发明名称 |
TRANSDERMAL FORMULATIONS FOR DELIVERY OF BERBERINE COMPOUNDS, AND THEIR USE IN THE TREATMENT OF BERBERINE-RESPONSIVE DISEASES AND CONDITIONS |
摘要 |
The present application is directed to transdermal formulations for the delivery of berberine compounds to a subject for the treatment of berberine-responsive diseases. In particular, the transdermal formulation comprises: (a) an aqueous phase comprising water and at least one water soluble emulsion stabilizer; (b) an oil phase comprising at least one emulsifier, at least one oil soluble emulsion stabilizer, at least one emollient comprising at least one flavonoid and at least one other emollient; wherein the oil and aqueous phases form an emulsion; (c) an external phase comprising at least one flavonoid containing-extract, at least one phospholipid-complexed flavonoid and at least one source of berberine or analog or derivative thereof; and optionally (d) at least one preservative phase. |
申请公布号 |
WO2017027971(A1) |
申请公布日期 |
2017.02.23 |
申请号 |
WO2016CA50965 |
申请日期 |
2016.08.17 |
申请人 |
DELIVRA INC. |
发明人 |
GABRIELE, Joseph;BARANOWSKI, David;BUCHANAN, Beth;ZUCCOLO, Jonathan;TERIS, Mikaela |
分类号 |
A61K31/4745;A61K9/00;A61K9/10;A61K9/107;A61K31/155;A61K31/64;A61K36/29;A61K36/71;C07C279/26;C07C311/59;C07D455/03 |
主分类号 |
A61K31/4745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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