| 发明名称 |
METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS |
| 摘要 |
The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose |
| 申请公布号 |
US2017051052(A1) |
申请公布日期 |
2017.02.23 |
| 申请号 |
US201615345953 |
申请日期 |
2016.11.08 |
| 申请人 |
AbbVie Inc. |
发明人 |
Bengea Cornelia;Rives Lisa M.;Hossler Patrick |
| 分类号 |
C07K16/24;C12P21/00 |
主分类号 |
C07K16/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for controlling the galactosylation profile of a recombinantly-expressed protein comprising supplementing a production media used in the recombinant expression of said protein with a manganese supplement and/or a galactose supplement. |
| 地址 |
North Chicago IL US |
