| 发明名称 |
PEPTIDE AGONISTS OF TOLL-LIKE RECEPTOR 5 LIGAND AND METHOD OF USE |
| 摘要 |
The present invention refers to peptides functionally related to Toll-like receptor 5 (TLR-5) ligand, having a sequence of amino acids ordered by means of the protein informational analysis techniques using the informational spectrum method with reference to the informational properties of flagellin. The sequence has in the informational spectrum the frequency of virtually the same value as the frequency characteristic determining the flagellin/TLR-5 interaction. |
| 申请公布号 |
US2017051021(A1) |
申请公布日期 |
2017.02.23 |
| 申请号 |
US201515307390 |
申请日期 |
2015.04.29 |
| 申请人 |
CENTRO DI RIFERIMENTO ONCOLOGICO ;VINCA INSTITUTE OF NUCLEAR SCIENCES |
发明人 |
COLOMBATTI Alfonso;DOLIANA Roberto;VELJKOVIC Veljko;VELJKOVIC Nevena;GLISIC Sanja;PEROVIC Vladimir |
| 分类号 |
C07K14/255;A61K45/06;G01N33/68;A61K39/39;A61K47/48;A61K38/16;C07K16/12 |
主分类号 |
C07K14/255 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated polypeptide which polypeptide presents substantially the same frequencies as natural flagellin in the informational cross-spectrum with human toll-like receptor-5 (TLR-5), obtained by Fourier transformation according to the method of the informational spectrum analysis, wherein in the informational spectrum as a dominant the frequency component F is in the region 0.404-0.407, preferably 0.405. |
| 地址 |
Aviano IT |
