主权项 |
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof,wherein,
Ring A is an optionally substituted 5- or 6-membered heteroaryl ring containing at least one S or N atom, or an optionally substituted 5- or 6-membered heterocyclyl ring containing at least one S or N atom; X2 is N or C—R12, in which R12 is hydrogen, halogen, alkyl, or alkoxy; X5 is N or C—R15, in which R15 is hydrogen, halogen, —CN, alkyl or alkoxy; X6 is N or C—R16, in which R16 is hydrogen, halogen, or —W—X, wherein W is a bond, —O—, —S—, or —NH—, and X is alkyl, alkynyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkynyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and G is: wherein,
R22 is alkyl;R23 is hydrogen, halogen, or alkyl; or optionally, when R23 is alkyl, R22 and R23 join to form an optionally substituted ring;R25 is hydrogen, halogen, alkyl, alkoxy, or alkenyl;R26 is hydrogen, halogen, alkyl, alkoxy, aminoalkyl, or alkenyl; or optionally, when R23 is hydrogen, R25 is not hydrogen and R26 is not hydrogen or halogen, R25 and R26 join to form an optionally substituted ring;provided that the compound of Formula I is not: 4-(3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-2-methylisoquinolin-1(2H)-one; 2-methyl-4-(2-oxoindolin-6-yl)isoquinolin-1(2H)-one; 4-methyl-6-(2-methyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-2H-benzo[b][1,4]oxazin-3 (4H)-one; nor 4-(1′-cyclobutyl-4H-spiro[benzo[d][1,3]dioxine-2,4′-piperidine]-6-yl)-2-methylisoquinolin-1(2H)-one. |