PROBE INVERSION PROCESS FOR IN SITU SYNTHESIZED PROBE ARRAYS

摘要

The present disclosure relates to processes for inverting oligonucleotide probes in an in situ synthesized array. These processes can be used to reverse the orientation of probes with respect to the substrate from 3 '-bound to 5 '-bound. These processes can also be used to reduce or eliminate the presence of truncated probe sequences from an in situ synthesized array.