| 摘要 |
Ketamine drug intermediates cyclopentene synthesis method, comprising the following steps: tubular reactor was added 1.56 mol nickel oxide, added 1.3mol cyclopentylamine (2), added 1.6-1.9mol 1-nitrotoluene solution(3), added 300ml oxalic acid solution, reaction temperature was increased to 270-280C, continued reaction for 90-120min, then raising the temperature to 300-310 C, the reaction was continued 50-70min, after the thermal cracking reaction, the reactor temperature was lowered to 20 -25 C, condensed vapor, the aqueous layer was separated, oil layer was washed with salt solution , washed with xylene solution, dehydrated with dehydrating agent, recrystallized in the acetamide solution, got crystal cyclopentene. |
