发明名称 |
PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL AGENT |
摘要 |
This invention provides a process for providing phosphoramidate derivatives, comprising performing a nucleophilic substitution reaction at phosphorous, where a phosphoryl chloride derivative is reacted with an oxime derivative to provide activated phosphoramidate intermediates, the intermediates find utility in a second nucleophilic substitution reaction where an activated phosphoramidate is reacted with a primary alcohol-containing sugar derivative, wherein the product of the reaction is sofosbuvir. |
申请公布号 |
EP3133062(A1) |
申请公布日期 |
2017.02.22 |
申请号 |
EP20150460045 |
申请日期 |
2015.08.19 |
申请人 |
Zaklady Farmaceutyczne Polpharma SA |
发明人 |
KOSIK, Kamil;SAGOL, Karol;GODZISZ, Mateusz |
分类号 |
C07D219/06;C07C15/00;C07D239/60;C07D405/04;C07F9/24 |
主分类号 |
C07D219/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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