发明名称 Tetrahydronaphthyridinyl propionic acid derivatives and uses thereof
摘要 The present application relates to use of compounds of formula I for treating or preventing a fibrosis.
申请公布号 US9572801(B2) 申请公布日期 2017.02.21
申请号 US201615142023 申请日期 2016.04.29
申请人 SciFluor Life Sciences, Inc. 发明人 Askew Ben C.;Edwards D. Scott
分类号 A61K31/4709;A61K31/444;A61K31/4375;A61K31/4178 主分类号 A61K31/4709
代理机构 Cooley LLP 代理人 Cooley LLP ;Erlacher Heidi A.;Chen Chen
主权项 1. A method of treating or preventing a fibrosis, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I:or a pharmaceutically acceptable salt or solvate thereof, wherein: X1-X2 is CHR1—CH2, CH═CH, or C(O)—CH2; R1 is H or OH; Q1 is YY′ is CR3═N, CR4═CR4, or C(O)—NH; R3 is C1-C3 alkoxy, F, or R3, together with R2 and the carbon atoms to which they are attached, form a phenyl ring; each R4 is independently C1-C3 alkoxy, F, or two R4, together with the carbon atoms to which they are attached, form a 5- or 6-membered heterocyclic ring comprising one or two heteroatoms selected from N and O; R2 is H or together with R3 and the carbon atoms to which they are attached, form a phenyl ring; and Q2 is
地址 Cambridge MA US
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