主权项 |
1. A method of treating or preventing a fibrosis, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I:or a pharmaceutically acceptable salt or solvate thereof, wherein:
X1-X2 is CHR1—CH2, CH═CH, or C(O)—CH2; R1 is H or OH; Q1 is YY′ is CR3═N, CR4═CR4, or C(O)—NH; R3 is C1-C3 alkoxy, F, or R3, together with R2 and the carbon atoms to which they are attached, form a phenyl ring; each R4 is independently C1-C3 alkoxy, F, or two R4, together with the carbon atoms to which they are attached, form a 5- or 6-membered heterocyclic ring comprising one or two heteroatoms selected from N and O; R2 is H or together with R3 and the carbon atoms to which they are attached, form a phenyl ring; and Q2 is |