Layered drug delivery device

摘要

The layered drug delivery devices of the present invention have an outer side and an inner side. The device includes, in order from the outer side to the inner side, a first layer and a second layer. The first layer wherein the first layer is water insoluble, water swellable, and water permeable. The second layer includes a therapeutic amount of a water soluble drug and a water soluble mucoadhesive film. The second layer is disposed such that water passing through said first layer solubilizes the drug. The said solubilized drug then can permeate through a mucosal membrane when the inner side is in contact with the mucosal membrane. The drug delivery device is in sheet form.

主权项

1. A layered drug delivery device having an outer side and an inner side, the device comprising in order from the outer side to the inner side:
a first layer wherein the first layer is homogenous, water insoluble, water swellable, and water permeable when swelled, and a second layer comprising a therapeutic amount of a water soluble drug and a water soluble mucoadhesive film, said second layer disposed such that water passing through said first layer hydrates the second layer and solubilizes the drug, wherein said solubilized drug can permeate through a mucosal membrane when the inner side is in contact with the mucosal membrane,wherein the drug delivery device is in sheet form, andwherein the first layer and the second layer are in direct contact.