Cyclosporin derivatives for the treatment and prevention of a viral infection

摘要

The present invention relates to a compound of the formula (I), (II), (III), (IV), (V), or (VI) or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing a viral infection using the same.;

主权项

1. A compound of the formula (II): or pharmaceutically acceptable salt thereof, wherein the symbols have the following meanings and are, for each occurrence, independently selected: R1 is n-butyl or (E)-but-2-enyl; R2 is ethyl, 1-hydroxyethyl, isopropyl or n-propyl; W is O, or S; each occurrence of R3 is:
(C3-C6)alkyl substituted by one or more groups R4 each occurrence of which is independently selected from the group consisting of ORa′, SRa′, O(CH2)mOH, O(CH2Om(CH2)mOH, C(═O)(C1-C6)alkyl, C(═O)OH, C(═O)O(C1-C6)alkyl, —NRARB, and —NRC(CH2)mNRARB; wherein each occurrence Ra′ is independently H or alkyl;(C3-C6)alkynyl substituted by one or more groups which may be the same or different selected from the group consisting of hydroxy, amino, monoalkylamino and dialkylamino; or(C3-C6)alkenyl substituted by one or more groups which may be the same or different selected from the group consisting of hydroxy, amino, monoalkylamino and dialkylamino; each occurrence of R5 is H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, or aryl or substituted aryl; each occurrence of RA and RB is independently:
hydrogen;(C1-C6)alkyl, optionally substituted by one or more groups RD which may be the same or different;(C2-C6)alkenyl or (C2-C6)alkynyl;(C3-C7)cycloalkyl optionally substituted with (C1-C6)alkyl;phenyl optionally substituted with from one to five groups which may be the same or different selected from halogen, —O(C1-C6)alkyl, —C(═O)O(C1-C6)alkyl, amino, alkylamino and dialkylamino;or a heterocyclic ring which may be saturated or unsaturated containing five or six ring atoms and from one to three heteroatoms which may the same or different selected from nitrogen, sulfur and oxygen;or RA and RB, together with the nitrogen atom to which the are attached, form a saturated or unsaturated heterocyclic ring containing from three to seven ring atoms, which ring may optionally contain another heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and may be optionally substituted by from one to four groups which may be the same or different selected from the group consisting of alkyl, phenyl and benzyl; each occurrence of RC is independently hydrogen or (C1-C6)alkyl; each occurrence of RD is independently halogen, hydroxy, O(C1-C4)alkyl, C(═O)(C1-C4)alkyl, C(═O)O(C1-C4)alkyl; and m is an integer of 1, 2, 3, 4 or 5.