| 发明名称 | Urocortin 2 analogs and uses thereof | ||
| 摘要 | Disclosed are polypeptides that are analogs of urocortin 2 that have pharmacological activity similar to urocortin 2 but have improved water solubility compared to urocortin 2, and pharmaceutical compositions of the polypeptides of the present invention. Also disclosed are polynucleotides encoding the polypeptides, and methods of treating pathophysiological states employing pharmaceutical compositions of the polypeptides and polynucleotides of the present invention. In addition, disclosed are vectors and host cells that include a nucleic acid encoding a polypeptide of the present invention, and kits that include pharmaceutical compositions of the present invention. | ||
| 申请公布号 | US9572866(B2) | 申请公布日期 | 2017.02.21 |
| 申请号 | US201514802812 | 申请日期 | 2015.07.17 |
| 申请人 | Research Development Foundation | 发明人 | Vale, Jr. Wylie W.;Vaughan Joan M.;Donaldson Cindy;Fischer Wolfgang;Rivier Jean E. F. |
| 分类号 | C07K14/47;A61K38/22;C07K14/575 | 主分类号 | C07K14/47 |
| 代理机构 | Parker Highlander PLLC | 代理人 | Parker Highlander PLLC |
| 主权项 | 1. An isolated nucleic acid molecule encoding SEQ ID NO: 6 or SEQ ID NO: 11 linked to a heterologous regulatory element. | ||
| 地址 | Carson City NV US | ||