| 主权项 |
1. A method of treating dermal wounds, comprising orally administering to a patient in need thereof a therapeutically effective amount of a formulation comprising a compound of Formula I, in liquid or solid form: wherein:
A is an antioxidant having the structure of Formula II: and/or reduced form thereof, wherein:
m comprises an integer from 1 to 3;Y is methyl;L is a linker group, comprising a straight or branched hydrocarbon chain optionally substituted by one or more double or triple bond, or ether bond, or ester bond, or C—S, or S—S, or peptide bond; and which is optionally substituted by one or more substituents selected from alkyl, alkoxy, halogen, keto group, amino group;n is an integer from 1 to 20; andB is a targeting group, and is:
a Skulachev ion Sk+Z−, wherein:
Sk is a lipophilic cation or a lipophilic metalloporphyrin; andZ is a pharmaceutically acceptable anion, the compound being stabilized in about 10% to about 100% of a liquid solvent selected from the group consisting of propylene glycol and glycerol. |
