Aβ protofibril binding antibodies

摘要

The present invention relates to the amyloid beta peptide (Aβ) and more specifically to antibodies binding to Aβ protofibrils and their use in therapy and/or prophylactic treatment of Alzheimer's disease and other disorders associated with Aβ protein aggregation. Further the invention may relate to diagnosis of such diseases as well as monitoring of disease progression by use of the antibodies of the invention. Further, the invention may relate to veterinary use of the antibodies of the invention.

主权项

1. An antibody or antigen binding fragment thereof having affinity against Aβ protofibrils, wherein the antibody or antigen binding fragment thereof has a variable light chain according to SEQ ID NO: 8, wherein
x1 (Xaa at position 17 of SEQ ID NO:8) is selected from A, D, E and Q, or a functional analogue thereof; x2 (Xaa at position 79 of SEQ ID NO:8) is selected from R, T, K, A and G, or a functional analogue thereof; x3 (Xaa at position 82 of SEQ ID NO:8) is selected from R, S, C, G and N, or a functional analogue thereof; y1 (Xaa at position 13 of SEQ ID NO:8) is selected from V and A; y2 (Xaa at position 21 of SEQ ID NO:8) is selected from I and V; y3 (Xaa at position 81 of SEQ ID NO:8) is selected from S and Q; y4 (Xaa at position 84 of SEQ ID NO:8) is selected from E and D; and optionally a variable heavy chain according to SEQ ID NO: 14, wherein z1 (Xaa at position 37 of SEQ ID NO:14) is selected from V and I; z2 (Xaa at position 38 of SEQ ID NO:14) is selected from R and Q; and z3 (Xaa at position 40 of SEQ ID NO:14) is selected from A, N and T; with the exception for the combination x1=A, x2=R and x3=R.