| 发明名称 |
Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent |
| 摘要 |
The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof. |
| 申请公布号 |
US9574016(B2) |
申请公布日期 |
2017.02.21 |
| 申请号 |
US201414539009 |
申请日期 |
2014.11.12 |
| 申请人 |
Hoffmann-La Roche Inc. |
发明人 |
Brinkmann Ulrich;Croasdale Rebecca;Lau Wilma;Georges Guy;Haas Alexander;Hoffmann Eike;Metz Silke;Mundigl Olaf;Scheuer Werner;Stracke Jan Olaf |
| 分类号 |
C07K16/44;A61K31/704;A61K39/395;A61K47/48;B82Y5/00;C07K16/28;C07K16/32;C12N15/11;C12N15/113;A61K49/00;C07K16/30;C12Q1/68;A61K39/00 |
主分类号 |
C07K16/44 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A humanized antibody specific against digoxigenin (DIG) comprising an antigen binding site that binds to digoxigenin and that comprises a heavy chain variable domain of SEQ ID NO: 3 comprising the mutations S49A, I57A and A60P (numbering according to Kabat), and a light chain variable domain of SEQ ID NO: 5. |
| 地址 |
Little Falls NJ US |
