| 摘要 |
L-proline drug intermediates L-glutamic acid-y-ethyl ester synthesis method, comprising the following steps: equipped with a stirrer, a thermometer, a reflux condenser, a dropping funnel, the reaction vessel was added 1.1mol L-glutamic acid (2), 1200ml phenylethyl alcohol solution, controlling the stirring speed 120-150rpm, the temperature of the solution is reduced to 3-5 C, was 100-120ml phosphoric acid solution slowly added, after the addition reaction continued for 90-120min, the solution temperature was increased to 40--45 C, reaction continued for 80-120min, then the reaction solution was clarified, 50ml potassium bicarbonate solution was added, and the pH of solution was maintained at 9-10, a white solid was precipitated, the temperature of the solution is reduced to 30-35 C, stirring speed was controlled at 160-180rpm, the reaction continued for 90-120min, the temperature of the solution is reduced to 7--1O0 C, filtered, the filter cake was washed with p-xylene solution, drying at low-pressure, got L-glutamic acid-y-ethyl ester. |
