| 发明名称 |
METHODS FOR TREATING T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA |
| 摘要 |
The present invention is directed to methods of treating T-ALL that involve administering an inhibitor of jumonji D3 (JMJD3) demethylase. Another embodiment of the invention relates to methods inhibiting T-ALL cell proliferation and/or survival that involves administering an inhibitor of jumonji D3 (JMJD3) demethylase to a population of T-ALL cells. |
| 申请公布号 |
US2017042904(A1) |
申请公布日期 |
2017.02.16 |
| 申请号 |
US201615237049 |
申请日期 |
2016.08.15 |
| 申请人 |
AIFANTIS Iannis;NTZIACHRISTOS Panagiotis |
发明人 |
AIFANTIS Iannis;NTZIACHRISTOS Panagiotis |
| 分类号 |
A61K31/55;C12N15/113;A61K45/06;A61K31/7088 |
主分类号 |
A61K31/55 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating T-cell acute lymphoblastic leukemia in a subject, said method comprising:
selecting a subject having T-cell acute lymphoblastic leukemia and administering, to the selected subject, an inhibitor of jumonji D3 (JMJD3) demethylase activity at a dosage effective to treat the T cell acute lymphoblastic leukemia in the subject. |
| 地址 |
Brooklyn NY US |
