| 主权项 |
1. A compound of formula (I) wherein E is selected from N and CRE; R1, R2 and RE are independently selected from H, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 hydroxyalkyl and C3-7 cycloalkyl; R3 is selected from (i) C1-4 alkyl which is unsubstituted or substituted with 1 or more substituents, particularly 1 to 3 substituents, independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 haloalkyl, C1-4 alkoxy, C1-4 alkyl, oxo, CN, —(C0-3 alkyl)-NR3aR3b, C3-7 cycloalkyl and C3-7 heterocyclyl, and wherein the C3-7 cycloalkyl or C3-7 heterocyclyl is unsubstituted or substituted with 1 to 3 substituents independently selected from from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b; (ii) C1-4 alkoxy which is unsubstituted or substituted with 1 or more substituents, particularly 1 to 3 substituents, independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 haloalkyl, C1-4 alkoxy, C1-4 alkyl, oxo, CN, —(C0-3 alkyl)-NR3aR3b, C3-7 cycloalkyl and C3-7 heterocyclyl, and wherein the C3-7 cycloalkyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b; (iii) C3-7 cycloalkyl or —O—C3-7 cycloalkyl wherein the C3-7 cycloalkyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b; (iv) a —(C0-3 alkyl)-C3-7 cycloalkyl or —O—(C0-3 alkyl)-C3-7 cycloalkyl wherein the C3-7 cycloalkyl is spiro fused to a second C3-7 cycloalkyl or C3-7 heterocyclyl by one single carbon atom, and wherein the C3-7 cycloalkyl or C3-7 heterocyclyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b; (v) a —(C0-3 alkyl)-C3-7 heterocyclyl or —O—(C0-3 alkyl)-C3-7 heterocyclyl, and wherein said C3-7 heterocyclyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b; (vi) a —(C0-3 alkyl)-C3-7 heterocyclyl or —(O—C0-3 alkyl)-C3-7 heterocyclyl, and wherein said C3-7 heterocyclyl is spiro fused to a second C3-7 heterocyclyl or a C3-7 cycloalkyl by one single carbon atom, and wherein the C3-7 heterocyclyl or C3-7 cycloalkyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b; (vii) H; R4 is selected from H and C1-4 alkyl; or R3 and R4 together with the nitrogen atom to which they are attached form a C3-7 heterocyclyl, which C3-7 heterocyclyl is optionally spiro fused to a second C3-7 heterocyclyl or a C3-7 cycloalkyl by one single carbon atom, and which C3-7 heterocyclyl and C3-7 cycloalkyl are unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b; R3a and R3b are independently selected from H, C1-4 alkyl and C1-4 haloalkyl; Y is a 5-6-membered heteroaryl, which heteroaryl is unsubstituted or substituted with 1 to 3 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4alkoxyC1-4alkyl, C1-4hydroxyalkyl, C1-4 alkoxy, C1-4 haloalkoxy, halogen, C1-4 hydroxyalkyl, —(C0-3 alkyl)-N′R″, —(C0-3 alkyl)-C3-7 cycloalkyl and —(C0-3 alkyl)-C3-7 heterocyclyl, —(C═O)—C3-7 heterocyclyl, —(C═O)—N′R″, —(C0-3 alkyl)-phenyl and —(C0-3 alkyl)-5-6-membered heteroaryl; R′ and R″ are independently selected from H and C1-4 alkyl; or a pharmaceutically acceptable salt thereof. |
