| 摘要 |
The invention relates to the field of the chemical and pharmaceutical industry, and more particularly to a method of producing S-ademetionine-based enteric capsules, which includes mixing S-ademetionine 1,4-butanedisulfonate with a polyvinylcaprolactam-polyvinyl acetate-polyethylene glycol copolymer with a molecular mass of 90000-140000 g/mol in a ratio of 30:70; micronizing the resultant mixture; adding excipients such as microcrystalline cellulose, Aerosil and stearic acid and/or a calcium or magnesium salt thereof; carrying out repeat micronization; and filling gelatin capsules with the resultant mixture with the following ratio of ingredients (g/capsule): 0.100 S-ademetionine 1,4-butanedisulfonate; 0.234 polyvinylcaprolactam-polyvinyl acetate-polyethylene glycol copolymer with a molecular mass of 90000-140000 g/mol; 0.221 microcrystalline cellulose; 0.0041 Aerosil; 0.004 stearic acid and/or a calcium or magnesium salt thereof. The invention provides an increase in the bioavailability of an oral formulation of ademetionine, permits the use of smaller curative doses of the drug and enables the controlled release thereof, while also providing a high therapeutic effect. |
