| 摘要 |
Gastric dynamic drug domperidone synthesis method comprising the following steps: the reaction vessel was added 0.12mol 5-chloro-1-(4-piperidinyl) - benzimidazol-2-one (3), 1100-1300ml nitromethane, 0.31-0.33mol sodium sulfite, 0.13-0.15mol 1 (3-aminopropyl) benzimidazole-2-one (2), 3-5g sodium bromide, controlling the stirring speed 110-130rpm, refluxed for 30-32 h, the reaction solution was poured into sodium chloride solution, the temperature of the solution was reduced to 3 - 5 C, to precipitate solid, the solid was washed with saline solution, washed with toluene solution, dehydrated with dehydrating agent, recrystallized in propionitrile solution, got white solid domperidone . |
