发明名称 |
ASSAYS FOR DETECTING NEUTRALIZING AUTOANTIBODIES TO BIOLOGIC THERAPY WITH TNF ALPHA |
摘要 |
The present invention provides assays for detecting and measuring the presence or level of neutralizing and non-neutralizing autoantibodies to biologics such as anti-TNF± drug therapeutics in a sample. The present invention is useful for monitoring the formation of neutralizing and/or non-neutralizing anti-drug antibodies over time while a subject is on biologic therapy. The present invention is also useful for predicting and/or determining the cross-reactivity of neutralizing anti-drug antibodies in a subject's sample with alternative biologic therapies. As such, the present invention provides information for guiding treatment decisions for those subjects receiving therapy with a biologic agent and improves the accuracy of optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment to biologic therapy. |
申请公布号 |
EP3130921(A1) |
申请公布日期 |
2017.02.15 |
申请号 |
EP20160177029 |
申请日期 |
2012.07.06 |
申请人 |
Nestec S.A. |
发明人 |
HAUENSTEIN, Scott;OHRMUND, Linda;SINGH, Sharat;WANG, Shui Long |
分类号 |
G01N33/538 |
主分类号 |
G01N33/538 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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