System and method for analysis of bio-metabolites for-use in image-guided surgery

摘要

A system for identifying a bio-marker using mass spectroscopy is provided that includes a sample receptacle configured to receive a tissue sample, a mass spectrometry apparatus configured to receive the tissue sample and analyze the tissue sample using a mass spectrometry process to generate mass spectrometry data, and a computer system that includes a computer processor having access to a non-transitory, computer-readable storage medium having stored thereon instructions. The instructions cause the computer processor to: receive the mass spectrometry data from the mass spectrometry apparatus; analyze the mass spectrometry data to determine a presence of 2-Hydroxyglutarate (2-HG) in the tissue sample; and generate a report indicating a health of the tissue sample based on the presence of 2-HG in the tissue sample.

主权项

1. A system for identifying a bio-marker using mass spectroscopy, the system comprising:
a sample receptacle configured to receive a tissue sample; a mass spectrometry apparatus configured to receive the tissue sample and analyze the tissue sample using a mass spectrometry process to generate mass spectrometry data; and a computer system including a computer processor having access to a non-transitory, computer-readable storage medium having stored thereon instructions that cause the computer processor to:
receive the mass spectrometry data from the mass spectrometry apparatus;analyze the mass spectrometry data to determine a relative abundance of a mass-to-charge ratio of about 147 m/z and a relative abundance of a mass-to-charge ratio of about 129 m/z, thereby indicating a presence of 2-Hydroxyglutarate (2-HG) in the tissue sample; andgenerate a report indicating a likelihood of cancer in the tissue sample based on the presence of 2-HG in the tissue sample.