Methods of treating a tauopathy

摘要

The present disclosure provides methods of treating a tauopathy, involving administering an anti-Tau antibody. The present disclosure also provides anti-Tau antibodies, and formulations comprising same, for use in the methods.

主权项

1. A method of treating a tauopathy in an individual, the method comprising administering to the individual a humanized antibody that specifically binds an epitope within an N-terminal portion of a human Tau polypeptide, wherein the humanized antibody comprises:
a) a light chain region comprising:
(i) a VL CDR1 comprising an amino acid sequence of SEQ ID NO:7;(ii) a VL CDR2 comprising an amino acid sequence of SEQ ID NO:8;(iii) a VL CDR3 comprising an amino acid sequence of SEQ ID NO:9; and(iv) a humanized light chain framework region; and b) a heavy chain region comprising:
(i) a VH CDR1 comprising an amino acid sequence of SEQ ID NO:10;(ii) a VH CDR2 comprising an amino acid sequence of SEQ ID NO:11;(iii) a VH CDR3 comprising an amino acid sequence of SEQ ID NO:12; and(iv) a humanized heavy chain framework region.