Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B

摘要

Inhibitors of HBV replication of formula (I);
including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R1 to R7 have the meaning as defined herein.
;The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

主权项

1. A compound of Formula (I) or a stereoisomer or tautomeric form thereof, wherein:is each of Ra, Rb, Rc, Rd, Re, Rf and Rg are independently selected from the group consisting of hydrogen and methyl; Rh is hydrogen; Ri is hydrogen; R1, R2 and R3 are independently selected from the group consisting of hydrogen, fluoro, chloro, bromo, —CHF2, —CH2F, —CF3, —CN and methyl; R6 is selected from the group consisting of C1-C6alkyl and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, said C1-C6alkyl and 3-7 membered saturated ring each optionally substituted with one or more substituents selected from the group consisting of fluoro and C1-C3alkyl, wherein said C1-C3alkyl is optionally substituted with one or more substituents selected from the group consisting of fluoro, —CN, and OH; R7 is hydrogen; or a pharmaceutically acceptable salt or a solvate thereof.