Silicone hydrogel lenses with relatively-long thermal stability

摘要

The invention provides silicone hydrogel ophthalmic lenses (in particular contact lenses) having relatively-long thermal stability and methods for making such ophthalmic lenses.

主权项

1. A soft contact lens comprising a silicone hydrogel material comprising:
(1) first repeating units derived from N,N-dimethylacrylamide; (2) second repeating units derived from a siloxane vinylic monomer of formula (Ia)  in which R″, R11 and R12 are methyl and m2 is 3; and (3) third repeating units derived from α,ω-acrylamide terminated polydimethylsiloxane or α,ω-bis(methacryloxyethoxypropyl)-terminated polydimethylsiloxane, wherein the soft contact lens has a relatively-long thermal stability as characterized by having an autoclave-induced change in elastic modulus,EM19⁢A⁢⁢C_-EM1⁢A⁢⁢C_EM1⁢A⁢⁢C_,of about 5% or less, wherein EM1AC is the averaged after-one-autoclave elastic modulus of the soft contact lens and is obtained by averaging the elastic modulus of 15 soft contact lenses measured after being autoclaved one sole time for 30 minutes at 121° C. in a phosphate buffered saline at a pH of 7.20±0.05 and EM19AC is the averaged after-19-autoclaves elastic modulus of the soft contact lens and is obtained by averaging the elastic modulus of 15 soft contact lenses measured after being stored and autoclaved 19 times each for 30 minutes at 121° C. in a phosphate buffered saline at a pH of 7.20±0.05.