主权项 |
1. A compound having the structure of Formula I
A-B-Q-V Formula I wherein A is: B is —(CH2)n—, —CH═CH—, —CH2—N(R22)—, —CH2—O—, —C(O)—CH2—C(O)—,or —C(O)NR22—, wherein n=0, 1 or 2;
E is —N(R22)— or oxygen; Q is —C(O)—, —(CH2)a—, —S(O2)— or —CH2—C(O)—, wherein a is 1 or 2; V is NR21R22, wherein b is 1 or 2 and a is 1 or 2; Y is NR22, N-Q-U, CR22R23, oxygen, S(O)n, N—C(S)—NR22R23, N—(C═N—CN)—NR22R23, N—(C═N—SO2CH3)—NR22R23, C═NOR22, C═N—NR22R23 or CH-Q-U, n is 0, 1 or 2; U is NR22R23, lower alkyl, haloalkyl, alkoxy, OR22 or hydrogen; X is hydrogen, alkyl, or —C≡CR9; R1 and R2 are independently —CH3 or —CH2CH3; R3 is hydrogen, —CH3 or —CH2CH3; Ra and Rb, are each independently hydrogen, deuterium or —CH3—; Rc and Rd, are each independently hydrogen, alkoxy, lower alkyl or alkenyl; R4 is —CH3, —CF3, —C2H5 or —C3H5; R5, R6 and R7 are each independently hydrogen, lower alkyl, halogen, dialkylamine, nitro or dialkylamine; Z is CR3, CH or nitrogen; R8 is —CH2— or —C(O)—; R9, R14 and R16 are each independently hydrogen, or —CH3; R10 is N—R13, sulfur or oxygen; R11 is ═N—, or ═C(CH3)—; R12 is lower alkyl, alkoxy or haloalkyl; R13 is phenyl, lower alkyl or haloalkyl; R15 is hydrogen or —C(O)CH3; R17 and R18 together are —(CH2)4— or —CH═CH—CH═CH—; R19 and R20 together are —CH2-C(CH3)2-CH2-C(O)— or —CH═CH—CH═CH—; R21 is hydrogen, —C(O)CH3, —CH3 or —CH2CH3; R22 and R23 are each independently hydrogen or lower alkyl; R24 and R25 are each independently hydrogen or —CH3; R26 is NR22R23 or alkoxy; or wherein R1 and R2 taken together or Ra and Rb taken together along with the carbon to which they are attached are cyclopropyl; or R24 and R25 taken together along with the two carbons to which they are attached are cyclopropyl; or R24 and R25 taken together is oxo; T is oxygen, —N(R16)— or sulfur; and E is oxygen, —N(R16)—, sulfur or —C(O)—; including pharmaceutically acceptable salts, solvates and hydrates thereof. |