| 主权项 |
1. A compound of formula (I):in which:
R1 represents a C2-6 alkyl, C3-7 cycloalkyl, C1-6 alkyloxy, —S(O)m—C1-6 alkyl, C1-6 fluoroalkyl, C1-6 fluoroalkyloxy, —(CH2)n—C3-9 cycloalkyl, —(CH2)n—C3-9 cycloalkyl, C2-6 -6 alkyl-OH, —(CH2)n—C1-6 alkyloxy, —(CH2)n—C1-6 fluoroalkyl, —(CH2)p—O—C1-6 fluoroalkyl, CORa, CN, NO2 or NR8R9 group, a halogen or a phenyl or heteroaryl group comprising either a) from 1 to 4 nitrogen atoms or b) an oxygen or sulphur atom and 1 or 2 nitrogen atom(s); [[these]] wherein the phenyl and heteroaryl groups can optionally be substituted with one to three identical or different Rb groups, R2 and R3 are identical or different and represent a hydrogen atom or a C1-9 alkyl, C3-9 cycloalkyl, C1-6 fluoroalkyl, —(CH2)r—C3-9 cycloalkyl, —C2-6 alkyl-OH, —(CH2)r—C1-6 alkyloxy, —(CH2)r—C3-7 cycloalkyl, —(CH2)r—C1-6 fluoroalkyl, or —(CH2)q—O—C1-6 fluoroalkyl group, optionally, the R2 and R3 groups can form, with the carbon atom which bears them, a C3-9 cycloalkyl group or a heterocycle, R4, R5, R6, R7 are identical or different and represent either a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkyloxy, —S(O)s—C1-6 alkyl, C1-6 fluoroalkyl, C1-6 fluoroalkyloxy, —(CH2)t—C3-9 cycloalkyl, —(CH2)t—C3-9 cycloalkyl, —C1-6 alkyl-OH, —(CH2)t—C1-6 alkyloxy, —(CH2)t—C1-6 fluoroalkyl, —(CH2)—O—C1-6 fluoroalkyl, CORd, CN or NR8R9′group, or a halogen or a phenyl or heteroaryl group comprising either a) from 1 to 4 nitrogen atoms or b) an oxygen or sulphur atom and 1 or 2 nitrogen atom(s); these phenyl and heteroaryl groups can optionally be substituted with one to three identical or different Rc groups, X represents CH or N; Y represents either a nitrogen atom, or a carbon atom substituted with a C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkyloxy, —S(O)v—C1-6 alkyl, C1-6 fluoroalkyl, C1-6 fluoroalkyloxy, —(CH2)l—C3-9 cycloalkyl, —(CH2)l—C3-9 cycloalkyl, C1-6 alkyl-OH, —(CH2)l—C1-6 alkyloxy, —(CH2)l—C1-6 fluoroalkyl, —(CH2)w—O—C1-6 fluoroalkyl, CORe, CN, NR10R11 or NO2 group, a hydrogen atom or a halogen or a phenyl or heteroaryl group comprising either a) from 1 to 4 nitrogen atoms or b) an oxygen or sulphur atom and 1 or 2 nitrogen atom(s); these phenyl and heteroaryl groups can optionally be substituted with one to three identical or different Rb groups, Ra, Rd and Re are identical or different and represent a C1-6 alkyl, C1-6 alkyloxy or NR12R13 group; Rb and Rc are identical or different and represent a halogen, or a C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkyloxy, —S(O)j—C1-6 alkyl, C1-6 fluoroalkyl, C1-6 fluoroalkyloxy, —(CH2)i—C3-7 cycloalkyl, OH, —(CH2)i—C3-7 cycloalkyl, C1-6 alkyl-OH, —(CH2)i—C1-6 alkyloxy, —(CH2)i—C1-6 fluoroalkyl, —(CH2)z—O—C1-6 fluoroalkyl, CORa, CN or NR14R15 group; R8 and R8′, are identical or different and represent a C1-6 alkyl, C3-7 cycloalkyl, —(CH2)f—C3-7 cycloalkyl or —(CH2)f—C1-6fluoroalkyl group; R9, R9′, R10, R11, R12, R13, R14and R15are identical or different and represent a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, —(CH2)g—C3-7 cycloalkyl or —(CH2)g—C1-6 fluoroalkyl group; optionally, the R8 and R9 groups can form, with the nitrogen atom which bears them, a heterocycle; optionally, the R8′, and R9′, groups can form, with the nitrogen atom which bears them, a heterocycle; optionally, the R10 and R11 groups can form, with the nitrogen atom which bears them, a heterocycle; optionally, the R12 and R13 groups can form, with the nitrogen atom which bears them, a heterocycle; optionally, the R14 and R15 groups can form, with the nitrogen atom which bears them, a heterocycle; f, g, i, l, n, r and t are different or identical and are equal to 1, 2 or 3; j, m, s and v are different or identical and are equal to 0, 1 or 2; p, q, u, w and z are different or identical and are equal to 2, 3 or 4; and also a pharmaceutically acceptable salt, solvate, hydrate conformer or rotamer thereof. |
