| 发明名称 |
Pancreatic Cancer Therapy and Diagnosis |
| 摘要 |
The present invention provides novel cancer therapeutics for treating pancreatic cancer, and novel diagnostic methods for detecting chronic pancreatitis and pancreatic cancer. The invention pertains to antagonists of dopamine receptors that inhibit the growth of pancreatic cancer cells. The invention in particular offers new therapy options based on the inhibition of the activity or expression of dopamine receptor D2 (DRD2). Diagnostic methods of the invention comprise the detection of the expression of DRD2 in pancreatic tissue. Diagnostic kits are also comprised. |
| 申请公布号 |
US2017035746(A1) |
申请公布日期 |
2017.02.09 |
| 申请号 |
US201515304598 |
申请日期 |
2015.04.17 |
| 申请人 |
Deutsches Krebsforschungszentrum Stiftung des Öffentlichenrechts ;The Royal Institution for the Advancement of Learning/McGill University |
发明人 |
POURIA Jandaghi;HOHEISEL Jörg;RIAZALHOSSEINI Yasser |
| 分类号 |
A61K31/454;A61K31/7068;A61K45/06 |
主分类号 |
A61K31/454 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating pancreatic cancer or chronic pancreatitis in a subject in need thereof, said method comprising administering an antagonist of a dopamine receptor to the subject. |
| 地址 |
Heidelberg DE |
