TREATMENT OF TUMORS EXPRESSING MUTANT P53

摘要

PDGFRb inhibitors and the use of such inhibitors to treat mutant p53-expressing tumors are described. The present disclosure encompasses the discovery that mutant p53-induced upregulation of the platelet-derived growth factor receptor b (PDGFRb) contributes to invasion and/or metastasis of tumors expressing mutant p53. Specifically, the present disclosure encompasses the discovery that mutant p53 can disrupt a p73/NF-Y complex (which can repress PDGFRB transcription), leading to transcription of PDGFRb. The present disclosure therefore provides, at least in part, PDGFRb modulators (e.g., activators or inhibitors) for use in medicine, and specifically in diagnosis, treatment and/or prevention (e.g., delay of onset) of certain disorders, e.g., cancer.

主权项

1. A method of treating or preventing tumor metastasis, comprising: detecting a mutant p53 polynucleotide or a mutant p53 polypeptide in a tumor; and contacting the tumor with a therapeutic agent that targets a platelet derived growth factor receptor (PDGFR).