METHOD OF ESTERIFICATION OF CARBOXYL GROUPS PRESENT ON MULTIHYDROXYL CYCLIC POLYENE MOLECULAR STRUCTURES CARRYING BASIC NITROGEN GROUPS

摘要

Disclosed is a process for the preparation of partricin alkyl esters which involves reacting partricin in a solvent with primary alkyl alcohols in the quantity of 5 to 1000 moles per mole of partricin in the presence of carbodiimides, and optionally in the presence of acylation catalysts and/or nitrogen bases or anhydrous acids.

主权项

1. A process for the preparation of partricin alkyl esters, which comprises reacting partricin with primary alkyl alcohols in amounts of 5 to 1000 moles per mole of partricin in a solvent, in the presence of carbodiimides selected from N,N′-diisopropylcarbodiimide, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide base and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide methyl iodide, and optionally in the presence of acylation catalysts and/or nitrogen bases or anhydrous acids.