发明名称 |
METHOD FOR PRODUCING PITAVASTATIN CALCIUM |
摘要 |
According to the present invention, pitavastatin calcium is safely produced at low cost with high yield and high selectivity in an industrial scale. This method for producing pitavastatin calcium is characterized by comprising a step (i) for obtaining a compound represented by general formula (3) through acetalization of a compound represented by general formula (1), a step (ii) for obtaining a compound represented by general formula (4) by reacting the compound represented by general formula (3) with an acid, and a step (iii) for hydrolyzing the compound represented by general formula (4), followed by reaction with a calcium compound. |
申请公布号 |
WO2017022846(A1) |
申请公布日期 |
2017.02.09 |
申请号 |
WO2016JP73056 |
申请日期 |
2016.08.05 |
申请人 |
API CORPORATION |
发明人 |
WATANABE, Naoyuki;IURA, Takanobu;OOMIYA, Hideki;NAGAHAMA, Masaki |
分类号 |
C07D215/14;A61K31/47;A61P3/06;C07B61/00;C12P17/12 |
主分类号 |
C07D215/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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