| 发明名称 |
SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-METHYLENE ANALOGS OF CALCITRIOL AND RELATED COMPOUNDS |
| 摘要 |
Disclosed are 2-methylene analogs of vitamin D3 and related compounds, their biological activities, and various pharmaceutical uses for these analogs. Particularly disclosed are 1α-hydroxy-2-methylene-vitamin D3, (20S)-1α-hydroxy-2-methylene-vitamin D3, and (5E)-1α,25-dihydroxy-2-methylene-vitamin D3, their biological activities, and various pharmaceutical uses for these compounds including methods of treating and/or preventing bone diseases and disorders. |
| 申请公布号 |
US2017036977(A1) |
申请公布日期 |
2017.02.09 |
| 申请号 |
US201615220035 |
申请日期 |
2016.07.26 |
| 申请人 |
Wisconsin Alumni Research Foundation |
发明人 |
DeLuca Hector F.;Sibilska Izabela K.;Sicinski Rafal R.;Plum Lori A. |
| 分类号 |
C07C35/21;C07F7/18 |
主分类号 |
C07C35/21 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound having a formula: wherein: X1, and X2, which may be the same or different, are each selected from hydrogen or a hydroxy-protecting group. |
| 地址 |
Madison WI US |
