Vaccines and methods to treat lyme disease in dogs

摘要

The instant invention provides an immunogenic composition comprising an antigenic fragment of OspA protein of Borrelia burgdorferi and a chimeric protein containing antigenic fragments of different phylotypes of OspC protein of Borrelia burgdorferi. Vaccines incorporating the immunogenic composition of the invention, as well as methods of preventing Lyme disease in dogs and/or protecting dogs from Lyme disease using the vaccines are also provided.

主权项

1. An immunogenic composition comprising:
A) a first protein comprising an amino acid sequence at least 95% identical to SEQ ID NO: 1; and B) a second protein, comprising immunodominant epitopes of OspC phylotypes F and N; wherein said composition is useful for preventing or reducing the pathological effects of infection with Borrelia burgdorferi in a canine, wherein said second protein comprises i) at least one of an amino acid sequence at least 95% identical to SEQ ID NO: 8 and an amino acid sequence at least 95% identical to SEQ ID NO: 9; and ii) an amino acid sequence 95% identical to SEQ ID NO: 32.