Reduction of TGF beta signaling in myeloid cells in the treatment of cancer

摘要

Methods of inhibiting metastasis in cancer patients are provided, wherein the methods comprise reducing TGFβ signaling, for example, by reducing TGFβ receptor II expression in myeloid cells. Vectors comprising a TGFβ receptor II RNAi nucleic acid sequence operably linked to a myeloid specific promoter also are provided. A method of diagnosing cancer in an individual by determining TGFβ receptor II expression in myeloid cells in the individual is provided. Additionally, a method of modulating TGFβ activity in myeloid cells in a cancer patient comprising administering a regulator of at least one of the GSK3 and PI3K pathways to the patient is provided.

主权项

1. A method of inhibiting metastasis in a cancer patient comprising reducing TGFβ receptor II expression in myeloid cells in the cancer patient, wherein the TGFβ receptor II expression is reduced by:
(a) mutating the nucleic acid sequence encoding TGFβ receptor II in myeloid cells, or (b) deleting the nucleic acid sequence encoding TGFβ receptor II or a portion thereof in myeloid cells.