发明名称 |
FREMGANGSMÅDE TIL AT IDENTIFICERE, EKSPANDERE, OG FJERNE ADULTE STAMCELLER OG CANCERSTAMCELLER |
摘要 |
The invention relates to the field of biochemistry, pharmacy and oncology. The invention particularly relates to the use of novel stem cell markers for the isolation of stem cells. The invention further relates to the obtained stem cells and their use in for example research or treatment, for example, for the preparation of a medicament for the treatment of damaged or diseased tissue.
In one of the embodiments, the invention provides a method for obtaining (or isolating) stem cells comprising
- optionally preparing a cell suspension from a tissue or organ sample
- contacting said cell suspension with an Lgr4, 5 or 6 binding compound
- identify the cells bound to said binding compound
- optionally isolating the stem cells from said binding compound. The invention further relates to means suitable for cancer treatment and even more specific for the treatment of cancer by eradicating cancer stem cells. |
申请公布号 |
DK2190978(T3) |
申请公布日期 |
2017.02.06 |
申请号 |
DK20080793835T |
申请日期 |
2008.08.08 |
申请人 |
Koninklijke Nederlandse Akademie van Wetenschappen |
发明人 |
CLEVERS, Johannes Carolus;BARKER, Nicholas;HAEGEBARTH, Andrea;VAN DE WETERING, Marcus Lambertus |
分类号 |
C12N5/071;A61K38/00;C07K14/72;C12N5/074 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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