发明名称 |
MULTIVALENT OLIGONUCLEOTIDE ASSEMBLIES |
摘要 |
Provided herein, inter alia, are double stranded oligonucleotide molecules and methods of making the molecules. The double stranded oligonucleotide molecules include a first oligonucleotide strand comprising a first nucleic acid sequence bound to a second nucleic acid sequence through a first spacer, wherein said second nucleic acid sequence is bound to a third nucleic acid sequence through a second spacer and a second oligonucleotide strand comprising a fourth nucleic acid sequence bound to a fifth nucleic acid sequence through a third spacer, wherein said fifth nucleic acid sequence is bound to a sixth nucleic acid sequence through a fourth spacer, wherein the second nucleic acid sequence and the fifth nucleic acid sequence are hybridized to form a double stranded nucleic acid core of said double stranded oligonucleotide. |
申请公布号 |
US2017029816(A1) |
申请公布日期 |
2017.02.02 |
申请号 |
US201615209545 |
申请日期 |
2016.07.13 |
申请人 |
City of Hope |
发明人 |
Swiderski Piotr |
分类号 |
C12N15/113;C12N15/11 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
1. A double stranded oligonucleotide molecule comprising:
a first oligonucleotide strand comprising a first nucleic acid sequence bound to a second nucleic acid sequence through a first spacer, wherein said second nucleic acid sequence is bound to a third nucleic acid sequence through a second spacer; and a second oligonucleotide strand comprising a fourth nucleic acid sequence bound to a fifth nucleic acid sequence through a third spacer, wherein said fifth nucleic acid sequence is bound to a sixth nucleic acid sequence through a fourth spacer, wherein the second nucleic acid sequence and the fifth nucleic acid sequence are hybridized to form a double stranded nucleic acid core of said double stranded oligonucleotide. |
地址 |
Duarte CA US |