TRUNCATED TRK B AND TRK C ANTAGONISTS AND USES THEREOF

摘要

Disclosed herein are compositions, methods, vectors, and kits comprising an antagonist of a truncated TrkC or a truncated TrkB. Also described herein are methods of diagnosing, treating and/or preventing a neurodegenerative disease or condition or a symptomatic or pre-symptomatic condition with alterations to synapses associated with an elevated expression level of a truncated TrkC or truncated TrkB isoform.

主权项

1. A pharmaceutical composition comprising:
a) a nucleic acid polymer that comprises at least 80% sequence identity to a nucleic acid sequence selected from SEQ ID NOs: 1-5 and 114-119, and wherein the nucleic acid polymer is at most 100 nucleotides in length; and b) a pharmaceutically acceptable excipient and/or a delivery vehicle.