发明名称 |
Advanced macromolecule transduction domain (aMTD) sequences for improvement of cell-permeability, polynucleotides encoding the same, method to identify the unique features of aMTDs comprising the same, method to develop the aMTD sequences comprising the same |
摘要 |
The present invention is to execute macromolecule intracellular transduction technology (MITT) for delivering biologically active macromolecules into the cells; specifically, by exploiting well-enhanced hydrophobic cell penetrating peptide (CPP) - advanced macromolecule transduction domain (aMTD) - to effectively transduce biologically active molecules into the plasma membrane, polynucleotides encoding the same, methods of identifying the same, systems of genetically engineering a biologically active molecule with much enhanced cell-permeability by using the same, methods of importing a biologically active molecule into a cell by using the same, and uses thereof. |
申请公布号 |
AU2015304194(A1) |
申请公布日期 |
2017.02.02 |
申请号 |
AU20150304194 |
申请日期 |
2015.08.17 |
申请人 |
Cellivery Therapeutics, Inc.;Daewoong, Jo |
发明人 |
Jo, Daewoong;Choi, Young Sil;Lee, Chang Su;Choi, Jun Hyeong |
分类号 |
C07K7/08;C07K19/00;G01N33/68 |
主分类号 |
C07K7/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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