| 主权项 |
1. A compound of general formula (I) wherein A represents a bivalent group selected from the group consisting of —S—, —S(═O)—, —S(═O)2—, —S(═O)(═NR5)—; L represents a C2-C6-alkylene group,
wherein said group is optionally substituted with(i) one substituent selected from hydroxy, C2-C3-alkenyl, C2-C3-alkynyl, C3-C4-cycloalkyl, hydroxy-C1-C3-alkyl, —(CH2)NR6R7, and/or(ii) one or two or three substituents, identically or differently, selected from halogen and C1-C3-alkyl,
with the proviso that a C2-alkylene group is not substituted with a hydroxy group,or whereinone carbon atom of said C2-C6-alkylene group forms a three- or four-membered ring together with a bivalent group to which it is attached, wherein said bivalent group is selected from —CH2CH2—, —CH2CH2CH2—, —CH2OCH2—; X, Y represent CH or N with the proviso that one of X and Y represents CH and one of X and Y represents N; R1 represents a group selected from C1-C6-alkyl-, C3-C6-alkenyl, C3-C6-alkynyl, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl, phenyl-C1-C3-alkyl- and heteroaryl-C1-C3-alkyl-,
wherein said group is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of hydroxy, cyano, halogen, C1-C6-alkyl-, halo-C1-C3-alkyl-, C1-C6-alkoxy-, C1-C3-fluoroalkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, —OP(═O)(OH)2, —C(═O)OH, —C(═O)NH2; R2 represents a group selected from a hydrogen atom, a fluoro atom, a chloro atom, a bromo atom, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-; R3, R4 represent, independently from each other, a group selected from a hydrogen atom, a fluoro atom, a chloro atom, a bromo atom, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-; R5 represents a group selected from a hydrogen atom, cyano, —C(═O)R8, —C(═O)OR8, —S(═O)2R8, —C(═O)NR6R7, C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl,
wherein said C1-C6-alkyl, C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-; R6, R7 represent, independently from each other, a group selected from a hydrogen atom, C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, benzyl and heteroaryl,
wherein said C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, benzyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, or R6 and R7, together with the nitrogen atom they are attached to, form a cyclic amine; R8 represents a group selected from C1-C6-alkyl-, halo-C1-C3-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, benzyl and heteroaryl,
wherein said group is optionally substituted with one, two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, or an enantiomer, diastereomer, salt, solvate or salt of solvate thereof. |
