PROCESS OF MAKING ADAMANTANAMIDES

摘要

An effective process of making adamantanamide, which process is fast, does not the use of organic solvents or labor-intensive isolation or purification of the product, by removal of organic solvent or by-products, and has improved yield and purity.

主权项

1. A process of making an adamantanamide, the process comprising the steps:
i. mixing 0.9 to 1 molar equivalents of an alkylamine and 1.0-1.5 molar equivalents of a base in sufficient water to obtain a concentration of the alkylamine in the aqueous solution between 0.1 to 1.0 M and the pH between 8 to 14; ii. heating the mixture to a temperature in the range of from 50° C. to 90° C., to obtain a heated aqueous basic solution of the alkylamine; iii. adding 1 molar equivalent of adamantanecarbonyl chloride to the heated aqueous basic solution of alkylamine, to obtain a bi-phasic mixture; iv. stirring the bi-phasic mixture of the alkylamine and the adamantanecarbonyl chloride and maintaining the temperature in the range of from 50° C. to 90° C., until the reaction is completed; v. stirring and allowing the reaction mixture to cool to below 30° C., to precipitate the adamantanamide product out of the reaction mixture; and vi. separating the adamantanamide product from the reaction mixture.