发明名称 |
METHODS OF ISOLATING (4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYL) BORONATES AND METHODS OF USING THE SAME |
摘要 |
Methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate include adding carbon dioxide gas or carbon dioxide solid (dry ice) to a solution comprising a 4-chloro-2-fluoro-3-substituted-phenylboronate, an inert organic solvent, and at least one lithium salt to react the at least one lithium salt with the carbon dioxide gas or carbon dioxide solid (dry ice) and form a mixture comprising the 4-chloro-2-fluoro-3-substituted-phenylboronate, the inert organic solvent, and a precipitated solid. The precipitated solid may be removed from the mixture. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronates to produce methyl-4-amino-3-chloro-6-(4-chloro-2-fluoro-3-substituted-phenyl)pyridine-2-carboxylates are also disclosed. A 4-chloro-2-fluoro-3-substituted-phenylboronate produced by one of the methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate is also disclosed, wherein the 4-chloro-2-fluoro-3-substituted-phenylboronate may be obtained at a yield of greater than or equal to about 90%. |
申请公布号 |
EP2797932(B1) |
申请公布日期 |
2017.02.01 |
申请号 |
EP20120861211 |
申请日期 |
2012.12.28 |
申请人 |
Dow AgroSciences LLC |
发明人 |
OPPENHEIMER, Jossian;MENNING, Catherine A.;HENTON, Daniel R. |
分类号 |
C07F5/02;C07B61/00;C07D213/803;C07D213/807 |
主分类号 |
C07F5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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