| 发明名称 | Targeting microRNAs for the treatment of fibrosis | ||
| 摘要 | Provided herein are compositions and methods for the modulation of miR-214 for the treatment and/or prevention of fibrosis and fibroproliferative conditions. | ||
| 申请公布号 | US9556435(B2) | 申请公布日期 | 2017.01.31 |
| 申请号 | US201514872564 | 申请日期 | 2015.10.01 |
| 申请人 | Regulus Therapeutics Inc. | 发明人 | Chau B. Nelson |
| 分类号 | A61K48/00;C07H21/02;C07H21/04;C12N15/113;A61K31/7088;A61K38/02;A61K45/06;A61K31/713;A61K31/7125 | 主分类号 | A61K48/00 |
| 代理机构 | McNeil Baur PLLC | 代理人 | McNeil Baur PLLC |
| 主权项 | 1. A method of treating, preventing, or delaying the onset of fibrosis comprising administering to a subject having fibrosis or at risk for developing fibrosis a compound comprising a modified oligonucleotide consisting of 8 to 12 linked nucleosides, and having a nucleobase sequence that is fully complementary to the nucleobase sequence of miR-214. | ||
| 地址 | San Diego CA US | ||