METHOD AND SYSTEM FOR LOCALIZING LEFT VENTRICULAR CONDUCTION NON-UNIFORMITY

摘要

Methods, devices and systems are provided for selecting one or more left ventricular multi-electrode pacing site(s). The methods, devices and systems measure arrival times of LV activation events for corresponding LV sensing sites, where the arrival times each correspond to a conduction time from an intrinsic ventricular event or delivery of a pacing pulse until sensing of the corresponding LV activation event. Site-to-site (STS) relative delays are calculated as differences between the arrival times associated with adjacent LV sensing sites. The STS relative delays represent STS arrival delays for corresponding combinations of the adjacent LV sensing sites. An LV electrode combination is identified that is associated with at least one of the STS relative delays that satisfy selection criteria, where the LV electrode combination corresponds to a target tissue region exhibiting a select degree of non-uniformity. The LV electrode combination is designated as a first LVEC pacing site from which to deliver LV pacing pulses.

主权项

1. A method for selecting a left ventricular (LV) multi-electrode (LVME) pacing site for an implantable medical device equipped for cardiac stimulus pacing using a multi-pole LV lead, the method comprising:
sensing LV activation events at multiple LV sensing sites, where the activation events are generated in response to intrinsic ventricular events or delivery of a pacing pulse; measuring arrival times of the LV activation events for the corresponding LV sensing sites, wherein the arrival times each correspond to a conduction time from the intrinsic ventricular events or the delivery of the pacing pulse until sensing of the corresponding LV activation event; calculating site-to-site (STS) relative delays as differences between the arrival times associated with adjacent LV sensing sites, the STS relative delays representing STS arrival delays for corresponding combinations of the adjacent LV sensing sites; identifying an LV electrode combination associated with at least one of the STS relative delays that satisfies selection criteria, the LV electrode combination corresponding to a target tissue region exhibiting a select degree of non-uniformity as indicated by the corresponding STS relative delay; and designating the LV electrode combination as a first LVEC pacing site from which to deliver LV pacing pulses.