PREVENTION AND TREATMENT OF AGING AND NEURODEGENERATIVE DISEASES

摘要

This application provides methods of identifying agents to treat or prevent neurodegenerative disease, and methods of using such agents, such as those that reduce mitochondrial ATP synthase (ATPsyn) activity resulting in the modulation of 5' AMP-activated protein kinase (AMPK) activity, ATP production, NAD+ production, NADH production, NADPH production and/or mitochondrial calcium levels, to treat or prevent a neurodegenerative disease. Also provided are compounds and methods of their use to treat or prevent (e.g., delay one or more signs of) aging. In some examples, decreasing mTor activity can be used to treat aging.