Compositions And Methods For Immunodominant Antigens of Mycobacterium Tuberculosis

摘要

Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen M. tuberculosis and their use in vaccines, therapeutic agents, and various diagnostic tests. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter

主权项

1. A method for the detecting presence of antibodies which specifically bind to antigens of M. tuberculosis and which are present in a bodily fluid sample, comprising contacting the sample with antigens of M. tuberculosis, wherein the antigens are encoded by at least two of nucleic acids Rv3344c (SEQ ID NO: 939), Rv3879c (SEQ ID NO: 962), Rv3333c (SEQ ID NO: 938), Rv3029c (SEQ ID NO:921), Rv2396 (SEQ ID NO:876), Rv2487c (SEQ ID NO:882), Rv2162c (SEQ ID NO:863), and Rv3043c (SEQ ID NO: 923), and detecting antibodies which bind to the antigens.